《2012KDIGO—AKI临床指南1》内容预览

The serum level (S) of creatinine is determined by its generation (G) from cells (muscle) and diet (protein, especially cooked meat), extrarenal elimination (E) by the gut, and urinary excretion (U x V) by the kidney. Urinary excretion is the sum of filtered load (GFR X P) and tubular secretion (TS). In the steady state, urinary excretion equals generation and extrarenal elimination.By substitution and rearrangement, GFR can be expressed as the ratio of the non-GFR determinants (G, TS, and E) to the serum level. Adapted with permission from American Society of Nephrology13 conveyed through Copyright Clearance Center,Inc.

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