《Pre-eclampsia Eclampsia and HELLP syndrome》内容预览

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Pre-Eclampsia

Definition-

“a disorder associated with pregnancy consisting of hypertension, proteinuria and new-onset dependent oedema, most commonly after 20 weeks of gestation”

Eclampsia

Definition-

“pre eclampsia complicated with seizures”

Diagnosis

Hypertension- syst > 140mmHg
or 30mm above pre-preg

diastolic > 90 mmHg
or 15mm above pre-preg
Two abnormal measurements, on two occasions, more than 6 hours apart

Epidemiology

Freq (US)
pre-eclampsia: 6-8% of pregnancies
eclampsia: 0.05-0.2%

Aetiology

Exact pathophysiology unknown
Possible causes-
dysfunction of the uteroplacental bed leading to vasoconstriction, platelet aggregation and hypercoagulability
altered CoV reactivity, vasospasm, microthrombi, implantation problems, hypertension etc

Mortality/Morbidity

Maternal: 8-36% most frequently related to seizure activity

Foetal: 13-30% most frequently related to iatrogenic prematurity

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