But this drug may not be worth the risk, said Dr. Marcel Levi of the University of Amsterdam and colleagues at Novo Nordisk.
Their **ysis of 35 studies found that the overall likelihood that an artery would clog was 68 percent higher with NovoSeven therapy compared to a placebo.
The risk of heart attack, angina or related complication more than doubled, the researchers reported in the New England Journal of Medicine .
People over 65 who got the drug were more than twice as likely to develop an unwanted clot in an artery than younger patients, they found. Those over 74 were three times more likely.
"This is a highly effective drug in patients with excessive blood loss in various circumstances. But the main message is you need to realize that there is a price to be paid," Levi said in a telephone interview.
"If a patient's bleeding so serious he or she may have a major problem or even die, you can accept the small increased risk of having an arterial thrombosis (clot)," Levi said.
近期,美国心脏学会(AHA)发布了家族性高胆固醇血症的相关事宜的科学声明,...[详细]
糖尿病与冠心病互为高危因素。当糖尿病与冠心病并存时,患者发生严重不良心血管...[详细]