【专业课件】Hodgkin Disease 内容预览：

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    neoplastic disorder with development of specific infiltrate containing pathologic Reed-Sternberg cells.  It usually arises in lymph nodes and spreads to contiguous groups. Extranodal presentation are rare.  Disease is associated with defective cellular immunity.

    Diagnosis of Hodgkin Disease
    is based on microscopic examination of lymph node or other involved tissue
    it requires identification of diagnostic Reed-Sternberg cells

    Classical  Hodgkin disease
    lymphocyte rich       
    nodular sclerosis 1 and 2   
    mixed cellularity      
    lymphocyte depletion             (LD)

    pathologic documentation by hemopathologist
    physical examination
    documentation of B symptoms
    laboratory evaluation
    complete blood count, ESR
    liver function tests
    renal function tests
    lactate dehydrogenase
    chest radiograph
    ultrasonography
    CT scan of chest, abdomen and pelvis
    bone marrow aspiration / biopsy (bilateral)

    Essential under certain circumstances
    liver biopsy
    gallium scan
    technetium bone scan
    bone radiographs

    MRI
    bipedal lymphangiogram
    staging laparotomy
    Useful but not essential tests
    cell-surface marker phenotypic analysis
    gene rearrangement analysis

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