《2010GINA5岁和5岁以下儿童哮喘的诊治全球战略》内容预览

Summary. Asthma is the most common chronic disease of childhood and the leading cause ofchildhood morbidity from chronic disease as measured by school absences, emergencydepartment visits, and hospitalions1. During the past two decades, many scienti?c advanceshave improved our understanding of asthma and our ability to manage and control it effectively.However, in children 5 years and younger, the clinical symptoms of asthma are variable and non-speci?c. Furthermore, neither airflow limitation nor airway inflammation, the main pathologichallmarks of the condition, can be assessed routinely in this age group. For this reason, to aid in thediagnosis of asthma in young children, a symptoms-only desc**tive approach that includes thede?nition of various wheezing phenotypes has been recommended2. In 1993, the Global Initiativefor Asthma (GINA) was implemented to develop a network of individuals, organizations, and publichealth of?cials to disseminate ***rmation about the care of patients with asthma while at the sametime assuring a mechanism to incorporate the results of scienti?c investigations into asthma care.Since then, GINA has developed and regularly revised a Global Strategy for Asthma Managementand Prevention. Publications based on the Global Strategy for Asthma Management andPrevention have been translated into many different languages to promote internationalcollaboration and dissemination of ***rmation. In this report, Global Strategy for AsthmaManagement and Prevention in Children 5 Years and Younger, an effort has been made to presentthe special challenges that must be taken into account in managing asthma in children during the?rst 5 years of life, including dif?culties with diagnosis, the ef?cacy and safety of drugs and drugdelivery systems, and the lack of data on new therapies. Approaches to these issues will varyamong populations in the world based on socioeconomic conditions, genetic diversity, culturalbeliefs, and differences in healthcare access and delivery. Patients in this age group are oftenmanaged by pediatricians and general practitioners routinely faced with a wide variety of issuesrelated to childhood diseases.

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