关键信息

    据评估，肺癌治疗对指南的依从率为44%到52%,其中老年患者及存在合并症的患者遵守率较低。依据指南治疗的获益和毒性均存在不确定性。较多的肺癌患者由于不符合临床试验的纳入标准而被排除（例如年龄太大、有合并症或处于边界性的表现状态）。进一步研究应当帮助明确指南中对于普通肺癌人群的合适治疗方法，以增加其适用范围。

    明确普通肺癌人群最佳治疗方案的进一步研究有助于将临床试验转化为临床实践。

    TAKE-HOME MESSAGE

    Adherence to treatment guidelines for lung cancer is estimated to range from 44% to 52%, with lower adherence for older patients and those with comorbidities. There is uncertainty regarding the benefit and toxicities of guideline treatments. Patients with lung cancer tend to have characteristics that may have been exclusion criteria for clinical trials （such as older age, comorbidities, or borderline performance status）。 Further research could help to define proper treatment of lung cancer to improve the applicability of the guidelines to the general population of lung cancer patients.

    Further research to define the best treatments in the general lung cancer population would help to translate evidence from clinical trials into clinical practice.