Hodgkin Disease 内容预览： 

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Hodgkin Disease 内容简介：

HodgkinDisease
Definition:
neoplasticdisorderwithdevelopmentofspecificinfiltratecontainingpathologicReed-Sternbergcells.Itusuallyarisesinlymphnodesandspreadstocontiguousgroups.Extranodalpresentationarerare.Diseaseisassociatedwithdefectivecellularimmunity.

HodgkinDisease
Incidence:

-2-4casesper100000population/year
-bimodalagedistribution:
15-35yearsandabove50years
-malepredominanceM:F=1,7:1

ClinicalPresentation
Nontenderlymphnodesenlargement(localised)
neckandsupraclaviculararea60-80%
mediastinaladenopathy50%
other(abdominal,extranodaldisease)
systemicsymptoms(Bsymptoms)30%
fever
nightsweats
unexplainedweightloss(10%per6months)
othersymptoms
fatigue,weakness,pruritus
cough,chestpain,shortnessofbreath,venacavasyndrome
abdominalpain,boweldisturbances,ascites
bonepain

DiagnosisofHodgkinDisease
isbasedonmicroscopicexaminationoflymphnodeorotherinvolvedtissue
itrequiresidentificationofdiagnosticReed-Sternbergcells

PathologicClassification
WHO
ClassicalHodgkindisease
lymphocyterich(LR)
nodularsclerosis1and2(NS)
mixedcellularity(MC)

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