美国学者的一项研究表明，在糖尿病诊断持续时间较长以及现时应用胰岛素的2型糖尿病患者中癌症负担增高。论文于2013年1月8日在线发表于《糖尿病护理》（Diabetes Care）。

此项研究从2009年行为危险因素监测系统参与者中纳入25,964例患者；受试者年龄≥18岁，并且均伴有糖尿病诊断。

结果显示，对潜在混淆因素进行校正之后，糖尿病诊断持续越长则癌症患病率越高。在诊断为2型糖尿病的成人中，糖尿病诊断时间≥15年的男、女性患者在各部位癌症估计患病率方面明显高于诊断时间<15年者。在男、女性受试者中，现时胰岛素应用者的各部位癌症估计患病率均约为未应用者的2.3倍。

To estimate the prevalence of diagnosed cancer according to duration of diagnosed diabetes and current insulin use among U.S. adults with diagnosed diabetes.

We analyzed data from 25,964 adults aged ≥18 years with diagnosed diabetes who participated in the 2009 Behavioral Risk Factor Surveillance System.

After adjustment for potential confounders, we found that the greater the duration of diagnosed diabetes, the higher the prevalence of diagnosed cancers (P < 0.0001 for linear trend). Among adults with diagnosed type 2 diabetes, the prevalence estimate for cancers of all sites was significantly higher among men (adjusted prevalence ratio 1.6 [95% CI 1.3–1.9]) and women (1.8 [1.5–2.1]) who reported being diagnosed with diabetes ≥15 years ago than among those reporting diabetes diagnosis <15 years ago. The prevalence estimate for cancers of all sites was ~1.3 times higher among type 2 diabetic adults who currently used insulin than among those who did not use insulin among both men (1.3 [1.1–1.6]) and women (1.3 [1.1–1.5]).

Our results suggest that there is an increased burden of diagnosed cancer among adults with a longer duration of diagnosed diabetes and among type 2 diabetic adults who currently used insulin.