Pre-eclampsia Eclam 内容预览： 

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Pre-eclampsia, Eclampsia and HELLP syndrome
Dr.Victor M De Leon Anzures
Hospital O,horan UCIA
Medicina Critica y Terapia Intensiva

“a disorder associated with pregnancy consisting of hypertension, proteinuria and new-onset dependent oedema, most commonly after 20 weeks of gestation”

Aetiology
Exact pathophysiology unknown
Possible causes-
dysfunction of the uteroplacental bed leading to vasoconstriction, platelet aggregation and hypercoagulability
altered CoV reactivity, vasospasm, microthrombi, implantation problems, hypertension etc

Mortality/Morbidity
Maternal: 8-36% most frequently related to seizure activity
Foetal: 13-30% most frequently related to iatrogenic prematurity

Signs
Hypertension
Tachycardia and tachypnoea
Creps or wheeze on auscultation
Neurological deficit
Hyperreflexia
Petechiae, intracranial haemorrhage
Generalised oedema
Small uterus for dates

Risk Factors
Low socioeconomic class
Multiple foetuses, or hydatid
Maternal age <20 or >35yrs
Primip
Gestational or pre-gestational DM
Renal disease
Afro Caribbean- twice as likely
Family history- four times the risk

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